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Phosphatase and Feedback Regulation of Raf-1 Signaling
Amardeep S. Dhillon, Alex von Kriegsheim, Joan Grindlay and Walter Kolch
volume 6 | issue 1
1 January 2007Pages: 3 - 7
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The Raf-1 kinase is an effector of Ras GTPases that lies at the apex of the three-tier Raf/MEK/ERK pathway. Raf-1 activation is a complex process that entails two major events – relief of autoinhibition imposed by the regulatory domain and kinase domain activation. Recent studies indicate that the transition of Raf-1 from an active to an inactive state bears similar complexity to the activation process. Both these events require dynamic changes in Raf-1 phosphorylation. Here, we discuss the critical role of phosphatases and feedback phosphorylation during activation and inactivation of Raf-1 signalling.
Authors
Amardeep S. Dhillon
Beatson Institute for Cancer Research, Glasgow U.K.
Alex von Kriegsheim
Beatson Institute for Cancer Research, Glasgow U.K.
Joan Grindlay
Beatson Institute for Cancer Research, Glasgow U.K.
Walter Kolch
The Beatson Institute for Cancer Research; Glasgow UK
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.