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Brief Report
TIS11D is a Candidate Pro-Apoptotic p53 Target Gene
Roger S. Jackson II, Yong-Jig Cho and Peng Liang
volume 5 | issue 24
15 december 2006Pages: 2889 - 2893
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A number of target genes for the tumor suppressor, p53, have been identified, however, the mechanisms that contribute to p53-dependent apoptosis remain to be fully elucidated. In a comprehensive screen for p53 target genes by differential display, we have identified TIS11D as a p53-inducible gene. Induction of TIS11D mRNA was confirmed by Northern Blot in response to p53 expression. Inducible expression of TIS11D resulted in inhibition of cell proliferation and apoptosis. These data suggest TIS11D as a candidate p53 target gene that may be part of the network of genes responsible for p53-dependent apoptosis.
Authors
Roger S. Jackson II
Vanderbilt University Medical Center, Nashville, TN
Yong-Jig Cho
Vanderbilt University Medical Center, Nashville, TN
Peng Liang
Vanderbilt University Medical Center, Nashville, TN
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.