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A Breaking Strategy for Topoisomerase IIβ/PARP-1-Dependent Regulated Transcription
Bong-Gun Ju and Michael G. Rosenfeld
volume 5 | issue 22
15 november 2006Pages: 2557 - 2560
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While diverse enzymatic activities are required for transcriptional initiation, a central question remains whether additional enzymatic activities involved in other cellular processes may also be critical for regulated gene activation. Recently, we reported that signal-dependent activation of gene transcription requires topoisomerase IIβ (Topo IIβ)-dependent, nucleosome-specific, transient double-stranded DNA break formation with subsequent activation of poly(ADP-ribose) polymerase-1 (PARP-1) enzymatic function, which causes local changes of chromatin architecture novel mechanistic link between gene transcription and components of the DNA damage/repair machinery, (Ju et al., Science 2006; 312: 1798-1802). Here, we discussed that possible molecular mechanism underling Topo IIβ/PARP-1/DNA-PK network in transcriptional initiation and many intriguing issues remain to be solved in the future.
Authors
Bong-Gun Ju
Howard Hughes Medical Institute; University of California, San Diego; La Jolla CA, USA
Michael G. Rosenfeld
Howard Hughes Medical Institute; University of California, San Diego; La Jolla CA, USA
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.