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Perspectives
Modulating Molecular Functions of p53 with Small Molecules
Shiraz Mujtaba, Lei Zeng and Ming-Ming Zhoug
volume 5 | issue 22
15 november 2006Pages: 2575 - 2578
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Association of the p53 with many human cancers makes it a valuable therapeutic target. Stress-induced molecular interactions of p53 with other effector proteins are immensely intertwined with regulation of its functions in orchestrating a wide array of cellular responses, thereby defying analysis of the underlying molecular mechanisms with conventional molecular and cellular biology methods. Recent discoveries of small molecules that can selectively modulate the molecular interactions of p53 offer promising opportunities to address the challenge of dissecting these complex mechanisms and increase the hope for pharmacological control of p53 for clinical benefits of cancer patients.
Authors
Shiraz Mujtaba
Mount Sinai School of Medicine, New York University; New York NY, USA
Lei Zeng
Mount Sinai School of Medicine, New York University; New York NY, USA
Ming-Ming Zhoug
Mount Sinai School of Medicine, New York University; New York NY, USA
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.