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Myc Overexpression Enhances Apoptosis Induced by Small Molecules
Hao Mo, Marina Vita, Marianne Crespin and Marie Henriksson
volume 5 | issue 19
1 october 2006Pages: 2191 - 2194
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The Myc oncogene is deregulated in a wide variety of human tumors hence the Myc pathway is regarded as an attractive target for tailored cancer treatment. We have recently identified two small molecules, MYRAs (Myc-pathway response agents), that induce apoptosis in a Myc-dependent manner and inhibit Myc-driven transformation. Here, we show that these compounds in addition have prominent effects in MYCN overexpressing neuroblastoma cells. A third compound, NSC308848, also induced apoptosis in Myc-overexpressing cells and inhibited Myc-induced cellular transformation. However, in contrast to the MYRAs, NSC308848 treatment resulted in decreased Myc protein levels and gave rise to inhibitory effects also on other transcription factors than Myc. Taken together, our findings suggest that these three small molecules can elicit a similar biological response by interfering with the Myc pathway at different levels.
Authors
Hao Mo
Karolinska Institutet
Marina Vita
Karolinska Institutet
Marianne Crespin
Karolinska Institutet
Marie Henriksson
Karolinska Institutet
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.