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Perspectives
MicroRNAs: A New Insight into Cancer Genome
Lin Zhang and George Coukos
volume 5 | issue 19
1 october 2006Pages: 2216 - 2219
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Cancer is a disease involving multi-step dynamic changes in the genome. However, studies on cancer genome so far have focused most heavily on protein-coding genes, and our knowledge on alterations of the functional non-coding sequences in cancer is largely absent. MicroRNAs (miRNA) are ~22 nt non-coding RNAs, which regulate gene expression in a sequence-specific manner via translational inhibition or mRNA degradation. Mounting evidence is showing that miRNAs may play important roles in tumor development, and a better understanding of their alteration in cancer genome and oncogenic property should contribute to the diagnosis and treatment of cancer.
Authors
Lin Zhang
University of Pennsylvania School of Medicine
George Coukos
University of Pennsylvania School of Medicine
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.