Perspectives

Emerging Roles of β-Arrestins

Volume 5, Issue 18   September 15, 2006
Pages 2060 - 2063
http://dx.doi.org/10.4161/cc.5.18.3212
Authors: F. Gregory Buchanan and Raymond N. DuBois

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Abstract:
Arrestins were originally characterized as structural adaptor proteins which modulate the desensitization and trafficking of seven-membrane-spanning receptors. From these seminal observations a multitude of novel functions for this gene family have arisen. Here we review the recently identified roles for β-arrestin including its nuclear function and roles in development, cellular migration, and metastasis.

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