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Cooperation between Different Cdc4/Fbw7 Isoforms May Be Associated with 2-Step Inactivation of SCFCdc4 Targets
Steven I. Reed
volume 5 | issue 17
1 september 2006Pages: 1923 - 1924
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The recent description of a role for an SCF ubiquitin ligase in prolyl isomerization rather than ubiquitin ligation has led to a 2-step model for inactivation of cyclin E and, possibly, other SCFCdc4 targets in mammalian cells. In this proposed model, targets of SCFCdc4 are first subjected to prolyl isomerization, creating a signal for translocation and sequestration in the nucleolus, where they are then multiubiquitylated.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.