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CtIP, a Multivalent Adaptor Connecting Transcriptional Regulation, Checkpoint Control and Tumor Suppression
Guikai Wu and Wen-Hwa Lee‡
volume 5 | issue 15
1 august 2006Pages: 1592 - 1596
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CtIP was originally characterized as an interacting protein for the transcriptional co-repressor CtBP. In addition to transcriptional regulation, CtIP plays an important role in the DNA damage response and cell cycle checkpoint control. Recent evidence points to a viral factor-like S phase promoting activity of CtIP in counteracting Rb repression to facilitate E2F-directed transactivation during the G1/S transition. Genetic studies in mice revealed the haploid insufficiency of CtIP in suppressing tumorigenesis associated with shortened life span. Thus, CtIP emerges as a multivalent adaptor that connects cell cycle checkpoint control, transcriptional regulation and tumor suppression.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.