Sign up for Table of Contents Alerts.
Email this page
Print this page
Perspectives
Transcriptional Regulation by the Proteasome as a Mechanism for Cellular Protein
Kathryn L. Auld and Pamela A. Silver
volume 5 | issue 14
15 july 2006Pages: 1503 - 1505
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.
Protein degradation mediated by the ubiquitin-proteasome system is a vitally important means of regulation for many cellular processes. An increasing body of evidence implicates the proteasome in the regulation of gene transcription through a variety of mechanisms, including transcription factor processing and proteasomechromatin association. Recently a genomic approach was used to elucidate the transcriptional effects of the proteasome in budding yeast [1]. Results indicate a positive role for proteasome activity in the transcription of several functional gene classes, including the ribosomal protein genes. In addition, proteasome activity was found to be required for the expression of Spt23 target genes, independent of the proteasomal processing of this transcription factor, suggesting cooperativity between two forms of transcriptional regulation by the proteasome. Here we discuss several implications of these findings, including a possible feedback mechanism between protein synthesis and protein degradation via the transcriptional regulation of ribosomal protein genes by the proteasome.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.