Email this page
Print this page
Perspectives
Immense Promises for Tiny Molecules: Uncovering miRNA Functions
Carlos le Sage and Reuven Agami
Volume 5, Issue 13July 1, 2006
Pages 1415 - 1421
This is an open-access article
Download PDF
If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.
With the human genome fully sequenced, the need to obtain functional knowledge of many genes became apparent. Amongst them is a large set of recently discovered genes with powerful promise: the microRNA family. Accumulating data assigned functions in a wide array of biological processes to some miRNAs. Here we review the main approaches used to identify and validate miRNAs and describe ways to discover their functions. As potential effectors of many cellular pathways, mis-expression of miRNAs has been implicated in human cancer.
Authors
- Carlos le Sage
- Reuven Agami
This is an open-access article
Download PDF
If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.
