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Effects of C/EBPα and C/EBPβ in BCR/ABL-Expressing Cells: Differences and Similarities
Clara Guerzoni, Giovanna Ferrari-Amorotti, Michela Bardini, Samanta A. Mariani and Bruno Calabretta
volume 5 | issue 12
15 june 2006Pages: 1254 - 1257
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C/EBPα and C/EBPβ, two transcription factors of the C/EBP family play important roles in the proliferation and differentiation of various cell types including myeloid progenitors . Expression of C/EBPα and C/EBPβ is repressed in myeloid blast crisis of Chronic Myelogenous Leukemia by mechanisms that involve translation repression which depends on the interaction of RNA-binding proteins with conserved binding sites in the 5’UTR of c/ebpα and c/ebpβ mRNA. Ectopic expression of C/EBPα and C/EBPβ in myeloid progenitors expressing the BCR/ABL oncogene inhibits proliferation, induces differentiation and suppresses leukemogenesis in mice, but C/EBPα is markedly more effective than C/EBPβ. The more potent effects of C/EBPα probably depends on protein-protein interaction with cell-cycle regulatory proteins, but the pattern of genes modulated by C/EBPα and C/EBPβ is not completely overlapping. This suggests that transcription-dependent and -independent effects are both involved and support the therapeutic potential of reactivating C/EBPα and C/EBPβ expression in leukemic cells.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.