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G1/S Cyclins Interact with Regulatory Subunit of PKA via A-Kinase Anchoring Protein, AKAP95
Tatjana Arsenijevic, Chantal Degraef, Jacques E. Dumont, Pierre P. Roger and Isabelle Pirson
volume 5 | issue 11
1 june 2006Pages: 1217 - 1222
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The mechanisms by which cyclins promote mammalian cell cycle progression have been a topic of intense investigation over the last decade. We previously described an interaction between D-type cyclins and A-kinase anchoring protein, AKAP95. Here, we demonstrate that AKAP95 can also bind cyclin E1. Association between AKAP95 and cyclins is displaced by CDKs. We show that these G1/S cyclins can interact with RII subunit of PKAα through AKAP95. The presence of alternate complexes cyclin-CDK and cyclin D/E-AKAP95-PKA.RIIα suggest different roles of G1/S cyclins and a wider biological importance of these interactions in cells.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.