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Minichromosome Maintenance Proteins as Markers for Proliferation Zones During Embryogenesis
Soojin Ryu and Wolfgang Driever
volume 5 | issue 11
1 june 2006Pages: 1140 - 1142
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Regulation of cell proliferation is of fundamental importance for growth and prevention of cancer. An obligatory step in the regulation of cell proliferation is the control of the initiation of DNA synthesis. The minichromosome maintenance (MCM) proteins are essential DNA replication factors crucial for initiating DNA synthesis once every cell cycle. Recent studies show that the level of MCM proteins is stringently regulated to correlate with cell proliferation and carcinogenesis. Here we discuss our recent data, which highlights the usefulness of minichromosome maintenance (MCM) gene expression for detecting proliferating cells as well as zones containing proliferative/stem cells during embryogenesis in a whole organism.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.