Bur1/Bur2 and the Ctk Complex in Yeast: The Split Personality of Mammalian P-TEFb
Volume 5, Issue 10
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May 15, 2006
Pages 1066 - 1068http://dx.doi.org/10.4161/cc.5.10.2769
Authors: Adam Wood and Ali Shilatifard View affiliations
Eukaryotic organisms possess a host of factors that regulate transcriptional elongation. In higher eukaryotes, the transcription factor P-TEFbβ not only regulates phosphorylation of the RNA polymerase II C-terminal domain, but it also inhibits the action of transcriptional repressors and is required for the association of several elongation factors with the transcribing polymerase. In the yeast Saccharomyces cerevisiae, the cyclin dependent kinases Bur1/Bur2 and Ctk complex (Ctk1, 2 and 3) are also able to impact several aspects of transcription. Together, these two kinase complexes appear to functionally reconstitute the activity of P-TEFβ in yeast. Recent findings regarding the role of these kinases in histone tail modifications and transcriptional regulation is briefly reviewed below.