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Perspectives
PI 3-Kinases: Hidden Potentials Revealed
Peter K. Vogt, Andreas G. Bader and Sohye Kang
volume 5 | issue 9
1 may 2006Pages: 946 - 949
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The potential oncogenicity of PI3-kinases is revealed by two principal mechanisms: mutations causing gain of function and over-expression of wild-type proteins. Cancer-specific mutations in PIK3CA, the gene coding for the catalytic subunit p110a of PI 3-kinase, are oncogenic in the animal. These mutations are therefore significant determinants of the oncogenic cellular phenotype in human tumors and are appropriate and promising targets for small molecule inhibitors. Over-expression of wild-type p110b, g, and d induces oncogenic transformation in cell culture. Although these non-alpha isoforms of PI 3-kinase have not been found mutated in human cancer, deregulated expression could contribute to cellular oncogenic properties and deserves increased attention.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.