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Brief Report
Absence of BRAF Gene Mutation in Non-Melanoma Skin Tumors
Massimo Libra, Grazia Malaponte, Valentina Bevelacqua, Roberta Siciliano, Paola Castrogiovanni, Alberto Fulvi, Giuseppe Micali, Giovanni Ligresti, Maria C. Mazzarino, Franca Stivala, Salvatore Travali and James A. McCubrey
volume 5 | issue 9
1 may 2006Pages: 968 - 970
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Basal cell carcinoma (BCC) is the most common skin cancer, and its incidence is increasing. It was proposed that the RAS oncogene significantly contributes to skin cancer development. Numerous BRAF mutations have been detected in melanoma biopsy specimens and cell lines. For the first time, in the present study, tumor biopsy specimens from 78 patients with BCC were screened for BRAF mutation within exons 11 and 15. Our results indicate that the BRAF gene does not appear to be frequently mutated in non-melanoma skin tumors such as BCC. These data suggest that other gene alterations may cause tumor development.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.