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Analytical Report
Prolonged Mitosis Versus Tetraploid Checkpoint: How p53 Measures the Duration of Mitosis
Mikhail V. Blagosklonny
volume 5 | issue 9
1 may 2006Pages: 971 - 975
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Degradation of p53 requires transcription, and therefore inhibitors of transcription cause p53 accumulation. When transcription resumes, the p53 that accumulated in turn induces p21. During mitosis, chromosomes are condensed, the nuclear envelope is dissolved and transcription is absent. And, if a cell stays in mitosis too long, (e.g. mitotic arrest caused by Taxol or nocodazole), then p53 accumulates. This explains how p53 can measure mitotic time and perhaps represents the most fundamental function of p53.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.