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Perspectives
E2F1 and Telomerase: Alliance in the Dark Side
Marta M. Alonso, Juan Fueyo, W.K. Alfred Yung and Candelaria Gomez-Manzano
volume 5 | issue 9
1 may 2006Pages: 930 - 935
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Cancer arises from a stepwise accumulation of genetic changes. Among these changes, deregulation of the Rb/E2F1 pathway and constitutively active telomerase are pivotal milestones for the attainment of immortality and maintaining the neoplastic phenotype. We recently showed the Rb/E2F1 pathway to be a direct modulator of telomerase activity in normal and cancer cells, specifically in malignant gliomas. In addition, we reported that the correlation between the levels of expression of E2F1 and hTERT -the catalytic subunit of telomerase- in a subset of patients with glioblastoma multiforme confers clinical relevance to the role of E2F1 in triggering or maintaining hTERT expression. Here we review the evidence supporting the mechanistic linkage between E2F1 and telomerase activation. We also consider the clinical implications of this association in terms of prognostic significance and opportunities for the development of new and more rational therapeutic strategies.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.