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Human Tumor Mutants in PI3K p110α Subunit
Zhenning Liu and Thomas M. Roberts
volume 5 | issue 7
1 april 2006Pages: 675 - 677
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The PI3K-Akt pathway is frequently upregulated in human tumors. Recently, somatic mutations of PIK3CA, encoding p110α catalytic subunit of Class IA PI3Ks, have been found in various cancers. The two most common types of p110α mutants, those in the helical and kinase domains, have been shown to be very potent in Akt activation and oncogenic transformation by several groups. Notably these common mutations may not enhance recruitment of p110α to the plasma membrane where its substrates are located. We have investigated the effect of membrane localization on common PIK3CA tumor mutants via myristoylation. In addition we have studied a third class of less frequent mutants in the p85-binding domain, in an attempt to gain insight into p85’s inhibitory effect on p110α. This article briefly reviews and extends the literature on mutant forms of p110α.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.