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Perspectives
Cyclin E Overexpression Reduces Infiltrative Growth in Breast Cancer: Yet Another Link Between Proliferation Control and Tumor Invasion
Pontus Berglund and Göran Landberg
volume 5 | issue 6
16 march 2006Pages: 606 - 609
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Overexpression of cyclin E is strongly linked to an aggressive phenotype and poor prognosis in breast cancer. Unexpectedly, it has been shown that cyclin E overexpression decreases mobility and invasiveness of breast cancer cells. In fact, in a study of 985 breast cancers, cyclin E correlated with less infiltrative growth. This suggests a novel function for cyclin E in breast cancer tumorigenesis and a mutual control of proliferation and invasive behavior.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.