Akt1 in Endothelial Cell and Angiogenesis
Volume 5, Issue 5
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March 1, 2006
Pages 512 - 518http://dx.doi.org/10.4161/cc.5.5.2538
Authors: Payaningal R. Somanath, Olga V. Razorenova, Juhua Chen and Tatiana V. Byzova View affiliations
Akt, also known as Protein kinase B (PKB), regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. Akt influences the expression and/or activity of various pro- and anti-angiogenic factors and Akt isoforms (Akt1, Akt2 and Akt3) have been proposed as therapeutic targets for angiogenesis-related anomalies such as cancer and ischemic injury.