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Geminin Regulates Multiple Steps of the Chromosome Inheritance Cycle
Kiku-e K. Tachibana and Erich A. Nigg
volume 5 | issue 2
16 january 2006Pages: 151 - 154
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Centrosome duplication like DNA replication must occur exactly once per cell cycle to maintain genomic stability. Cell fusion and microinjection assays gave rise to the concept of “licensing” and uncovered nuclear-intrinsic blocks to over-replication and recently also centrosome-intrinsic blocks to overduplication. The chromatin licence has been defined in molecular terms as the pre-replication complex (pre-RC) antagonised by its regulator geminin. Geminin prevents pre-RC assembly and over-replication in S and G2 phases. However, the mechanisms that limit centrosome duplication including a potential centrosome licence remain poorly understood. Here, we discuss our recent data demonstrating that loss of the licensing inhibitor geminin causes centrosome overduplication in addition to genomic over-replication. We present further evidence that geminin is an inhibitor of centrosome duplication. Therefore, geminin is involved in regulating multiple steps of the chromosome inheritance cycle, including DNA replication, centrosome duplication and chromosome segregation.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.