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Perspectives

The MicroRNA Pathway Plays a Regulatory Role in Stem Cell Division

H.R. Shcherbata, S. Hatfield, E.J. Ward, S. Reynolds, K.A. Fischer and H. Ruohola-Baker

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One of the key characteristics of stem cells is their capacity for self-renewal for long periods of time. In this respect, stem cells are similar to cancer cells, which also have the ability to escape cell cycle stop signals. Therefore, a critical question in stem cell and cancer biology is how cell division is regulated in these cell types. In this review, we summarize recent progress and describe future challenges to understanding the role the microRNA pathway plays in regulating mechanisms controlling stem cell division.

Authors

H.R. Shcherbata

S. Hatfield

E.J. Ward

S. Reynolds

K.A. Fischer

H. Ruohola-Baker

 Download PDF

If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.