Sign up for Table of Contents Alerts.
Email this page
Print this page
Perspectives
Control of Hepatic Differentiation by Activin/TGFβ Signaling
Frédéric Clotman and Frédéric P. Lemaigre
volume 5 | issue 2
16 january 2006Pages: 168 - 171
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.
During liver development, liver progenitors called hepatoblasts differentiate into hepatocytes or biliary cells. Recently, we showed that the segregation between hepatocytes and biliary cells is dependent on a gradient of Activin/TGFβ signaling, and that Activin/TGFβ signaling is controlled in fetal liver by transcription factors of the Onecut family. Here, we discuss candidate factors possibly involved in the formation of the Activin/TGFβ signaling gradient, how this gradient could integrate into a network of signaling pathways modulating hepatoblast differentiation, and the implications for human liver disease and therapy.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.