Sign up for Table of Contents Alerts.
Email this page
Print this page
Extra Views
Anaphase Topsy-Turvy: Cdk1 a Securin, Separase a CKI
Olaf Stemmann, Ingo H. Gorr and Dominik Boos
volume 5 | issue 1
1 january 2006Pages: 11 - 13
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.
Chromosome segregation in mitosis and meiosis is triggered by activation of a large protease, separase. While it has been known for some time that the anaphase inhibitor securin regulates separase activity recent work shows that this is only half the story. In vertebrates Cdk1-dependent inhibition of separase represents a second, securin-independent branch of anaphase regulation. Furthermore, an unanticipated ability of separase to inhibit Cdk1 suggests additional, non-proteolytic functions of separase.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.