Suppression of centrosome duplication and amplification by deacetylases
Volume 11, Issue 20
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October 15, 2012
Pages 3779 - 3791http://dx.doi.org/10.4161/cc.21985
: acetylation, centrosome, centrosome amplification, centrosome duplication, deacetylase, deacetylation, histone deacetylase (HDAC)
Authors: Hongbo Ling, Lirong Peng, Edward Seto and Kenji Fukasawa View affiliations
Centrosome duplication is controlled both negatively and positively by a number of proteins. The activities and stabilities of those regulatory proteins are in many cases controlled by posttranslational modifications. Although acetylation and deacetylation are highly common posttranslational modifications, their roles in the regulation of centrosome duplication had not been closely examined. Here, through focusing on the deacetylases, we investigated the role of acetylation/deacetylation in the regulation of centrosome duplication and induction of abnormal amplification of centrosomes. We found that the deacetylation event negatively controls centrosome duplication and amplification. Of the 18 total known deacetylases (HDAC1–11, SIRT1–7), ten deacetylases possess the activity to suppress centrosome amplification, and their centrosome amplification suppressing activities are strongly associated with their abilities to localize to centrosomes. Among them, HDAC1, HDAC5 and SIRT1 show the highest suppressing activities, but each of them suppresses centrosome duplication and/or amplification with its unique mechanism.
Received: June 27, 2012; Accepted: August 27, 2012; Published Online: September 28, 2012
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