VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes
Volume 11, Issue 19
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October 1, 2012
Pages 3666 - 3678http://dx.doi.org/10.4161/cc.21927
: Mps1, VDAC, centriole assembly, centrosome, kinase
Authors: Shubhra Majumder, Mark Slabodnick, Amanda Pike, Joseph Marquardt and Harold A. Fisk View affiliations
Centrioles are duplicated during S-phase to generate the two centrosomes that serve as mitotic spindle poles during mitosis. The centrosomal pool of the Mps1 kinase is important for centriole assembly, but how Mps1 is delivered to centrosomes is unknown. Here we have identified a centrosome localization domain within Mps1 and identified the mitochondrial porin VDAC3 as a protein that binds to this region of Mps1. Moreover, we show that VDAC3 is present at the mother centriole and modulates centriole assembly by recruiting Mps1 to centrosomes.
Received: August 17, 2012; Accepted: August 22, 2012; Published Online: August 30, 2012
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