Editorials: Cell Cycle Features

How a mismatch repair enzyme balances the needs for efficient lesion processing and minimal action on undamaged DNA

Volume 11, Issue 18   September 15, 2012
Pages 3345 - 3346
http://dx.doi.org/10.4161/cc.21843
Keywords: 5-methylcytosine, CpG site, DNA demethylation, DNA glycosylase, GT mispair, base excision repair, deamination, epigenetic regulation
Authors: Alexander C. Drohat, Edwin Pozharski and Atanu Maiti

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Abstract:
Comment on: Maiti A, et al. Proc Natl Acad Sci USA 2012; 109:8091-6.

Editorials: Cell Cycle Features to:
A Maiti, MS Noon, AD Jr MacKerell, E Pozharski, AC Drohat. Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA. Proc Natl Acad Sci U S A 2012; 109: 8091-6
PMID: 22573813 DOI: 10.1073/pnas.1201010109

Received: June 26, 2012; Accepted: July 20, 2012; Published Online: August 23, 2012

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