Human telomerase reverse transcriptase (hTERT) is a target gene of β-catenin in human colorectal tumors
Volume 11, Issue 17
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September 1, 2012
Pages 3331 - 3338http://dx.doi.org/10.4161/cc.21790
, carcinogenesis, colorectal cancer, eternal life, hallmark of cancer, β-catenin
Authors: Stefanie Jaitner, Jana A. Reiche, Achim J. Schäffauer, Elke Hiendlmeyer, Hermann Herbst, Thomas Brabletz, Thomas Kirchner and Andreas Jung View affiliations
The majority of colorectal cancers (CRCs) are characterized by a dysregulated canonical Wnt-signaling pathway leading to the stabilization and subsequent cellular increase and accumulation of β-catenin. After translocation into the nucleus, it acts as a transcription factor resulting in the expression of β-catenin target genes. These resemble most of the hallmarks of cancer except eternal life. The central mediator of this hallmark is hTERT (human telomerase reverse transcriptase). The hTERT gene is regulated, besides others, by the transcription factor c-Myc and, thus, indirectly via β-catenin as c-Myc is a β-catenin target gene. Interestingly, the expression patterns of hTERT and β-catenin, but not c-Myc are overlapping, probably because c-Myc is not only regulated by β-catenin, but also by many other transcription factors and pathways. Therefore, we argued that hTERT might be a direct target gene of β-catenin. In this study, we show evidence that β-catenin directly regulates the expression of the hTERT gene.
Received: July 27, 2012; Accepted: August 8, 2012; Published Online: August 16, 2012
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