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Review
Oncogenic β-Catenin Signaling Networks in Colorectal Cancer
Serge Y. Fuchs, Andrei V. Ougolkov, Vladimir S. Spiegelman and Toshinari Minamoto
volume 4 | issue 11
November 2005Pages: 1522 - 1539
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β-catenin has two distinct functions, namely, maintaining cell-to-cell adhesion and mediating the Wnt/β-catenin signal transduction pathway, which plays pivotal roles in embryogenesis and in malignant transformation of cells. The oncogenic properties of Wnt/β-catenin signaling stem from alteration in phosphorylation-dependent protein degradation and subcellular localization of β-catenin from cell membrane to the nucleus, where it binds to T-cell factor (Tcf) to form a bipartite transcription factor. The β-catenin/Tcf complex facilitates transcription of target genes that encode effectors for activation of cell proliferation and invasion and inhibition of apoptosis, leading to colorectal cancer development. In addition, in the tumor invasion front, stabilized and activated β-catenin interacts with other molecular pathways to facilitate tumor progression. This review highlights the β-catenin-dependent oncogenic signaling network involved in the multi-step process of colorectal tumorigenesis. Wnt signaling evidently regulates stem cells, leading them to differentiate or self-renew. We address roles of oncogenic β-catenin signaling in the microenvironment of the tumor-host interface that determine the individual tumor’s malignant potential and in regulation of putative cancer stem or progenitor cells that represent plausible targets for cancer eradication.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.