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The BTB-ZF transcription factors
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Pages 3358 - 3369
http://dx.doi.org/10.4161/cc.21277
Keywords: BTB, hematopoiesis, lymphoma, lymphopoiesis, zinc finger
Authors: Owen M. Siggs and Bruce Beutler
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Abstract:
The BTB-ZF (broad-complex, tramtrack and bric-à-brac - zinc finger) proteins are encoded by at least 49 genes in mouse and man and commonly serve as sequence-specific silencers of gene expression. This review will focus on the known physiological functions of mammalian BTB-ZF proteins, which include essential roles in the development of the immune system. We discuss their function in terminally differentiated lymphocytes and the progenitors that give rise to them, their action in hematopoietic malignancy and roles beyond the immune system.
Received: June 11, 2012; Accepted: June 26, 2012; Published Online: August 16, 2012
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