Cell Cycle News & Views

CTGF-mediated autophagy-senescence transition in tumor stroma promotes anabolic tumor growth and metastasis

Volume 11, Issue 14   July 15, 2012
Pages 2592 - 2593
http://dx.doi.org/10.4161/cc.21240
Authors: Varun V. Prabhu, Noel A. Warfel and Wafik S. El-Deiry

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Abstract:
Comment on: Capparelli C, et al. Cell Cycle 2012; 11:2272-84 and Capparelli C, et al. Cell Cycle 2012; 11:2285-302.

Cell Cycle News & Views to:
C Capparelli, D Whitaker-Menezes, C Guido, R Balliet, TG Pestell, A Howell, S Sneddon, RG Pestell, U Martinez-Outschoorn, MP Lisanti, F Sotgia. CTGF drives autophagy, glycolysis, and senescence in cancer associated fibroblasts via HIF1 activation, metabolically promoting tumor growth. Cell Cycle 2012; 11: 2272-2284
PMID: 22684333 DOI: 10.4161/cc.20717
and
C Capparelli, C Guido, D Whitaker-Menezes, G Bonuccelli, R Balliet, TG Pestell, AF Goldberg, RG Pestell, A Howell, S Sneddon, R Birbe, A Tsirigos, U Martinez-Outschoorn, F Sotgia, MP Lisanti. Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis, via glycolysis and ketone production. Cell Cycle 2012; 11: 2285-2302
PMID: 22684298 DOI: 10.4161/cc.20718

Received: June 14, 2012; Accepted: June 18, 2012

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