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Perspectives
Cell Cycle Sibling Rivalry: Cdc2 Versus Cdk2
Philipp Kaldis and Eiman Aleem
volume 4 | issue 11
November 2005Pages: 1491 - 1494
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It has been long believed that the cyclin-dependent kinase 2 [Cdk2] binds to cyclin E or cyclin A and exclusively promotes the G1/S phase transition and that Cdc2/cyclin B complexes play a major role in mitosis. We now provide evidence that Cdc2 binds to cyclin E [in addition to cyclin A & B] and is able to promote the G1/S transition. This new concept indicates that both Cdk2 and/or Cdc2 can drive cells through G1/S phase in parallel. In this review we discuss the classic cell cycle model and how results from knockout mice provide new evidence that refute this model. We focus on new roles of Cdc2 and p27 in regulating the mammalian cell cycle and propose a new model for cell cycle regulation that accommodates these novel findings.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.