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Could MYC Induction of Mitochondrial Biogenesis be linked to ROS Production and Genomic Instability?
Chi V. Dang, Feng Li and Linda A. Lee
volume 4 | issue 11
November 2005Pages: 1465 - 1466
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MYC has been linked separately to genomic instability and to reactive oxygen species production, but the connection between these two processes has not been firmly established. Our recent study along with previous reports demonstrate that Myc induces nuclear encoded mitochondrial gene expression and mitochondrial biogenesis, thereby directly associating Myc’s transcriptional properties, to the production of mitochondrial ROS and the promotion of genomic oxidative damage and genomic instability 1.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.