Review

Cell cycle regulation of Rho signaling pathways

Volume 11, Issue 16   August 15, 2012
Pages 3003 - 3010
http://dx.doi.org/10.4161/cc.21088
Keywords: Rho GTPases, cytokinesis, mitosis, phosphorylation, signaling pathways, transcriptional regulation, ubiquitylation
Authors: Muriel David, Dominique Petit and Jacques Bertoglio

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Abstract:
The dynamics of the actin cytoskeleton and its regulation by Rho GTPases are essential to maintain cell shape, to allow cell motility and are also critical during cell cycle progression and mitosis. Rho GTPases and their effectors are involved in cell rounding at mitosis onset, in chromosomes alignment and are required for contraction of the actomyosin ring that separates daughter cells at the end of mitosis. Recent studies have revealed how a number of nucleotide exchange factors and GTPase-activating proteins regulate the activity of Rho GTPases during these processes. This review will focus on how the cell cycle machinery, in turn, regulates expression of proteins in the Rho signaling pathways through transcriptional activation, ubiquitylation and proteasomal degradation and modulates their activity through phosphorylation by mitotic kinases.

Received: May 14, 2012; Accepted: June 11, 2012; Published Online: July 24, 2012

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