Sign up for Table of Contents Alerts.
Email this page
Print this page
Perspectives
Dynamics of Chromatin during the Repair of DNA Double-Strand Breaks
Jessica A. Downs and Jacques Cote
volume 4 | issue 10
october 2005Pages: 1373 - 1376
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.
Double strand breaks (DSBs) are arguably the most deleterious DNA lesion that a cell can sustain, and defects in the ability to detect and repair these breaks result in increased genomic instability and have been causatively linked to cancer. The repair of DNA DSBs must occur in the context of chromatin, and there is increasing evidence that the modulation of chromatin plays an integral role in the DNA DSB repair process. Here, we summarize a number of key findings, largely from studies performed in budding yeast, highlighting the role of chromatin in DNA DSB responses.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.