RGG motif proteins: Modulators of mRNA functional states
Volume 11, Issue 14
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July 15, 2012
Pages 2594 - 2599http://dx.doi.org/10.4161/cc.20716
Authors: Purusharth Rajyaguru and Roy Parker View affiliations
A recent report1 demonstrates that a subset of RGG-motif proteins can bind translation initiation factor eIF4G and repress mRNA translation. This adds to the growing number of roles RGG-motif proteins play in modulating transcription, splicing, mRNA export and now translation. Herein, we review the nature and breadth of functions of RGG-motif proteins. In addition, the interaction of some RGG-motif proteins and other translation repressors with eIF4G highlights the role of eIF4G as a general modulator of mRNA function and not solely as a translation initiation factor.
Received: April 11, 2012; Accepted: May 10, 2012
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