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Brief Report
Analysis of BRAF Mutation in Primary and Metastatic Melanoma
Massimo Libra, Grazia Malaponte, Patrick M. Navolanic, Pietro Gangemi, Valentina Bevelacqua, Lidia Proietti, Bibiana Bruni, Franca Stivala, Maria C. Mazzarino, Salvatore Travali and James A. McCubrey
volume 4 | issue 10
october 2005Pages: 1382 - 1384
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Mutation of BRAF has been proposed to contribute to melanoma development. However, it remains unclear whether or not BRAF mutation is associated with any particular stage of melanoma progression. Tumor biopsy specimens from patients with melanoma were analyzed to determine whether the frequency of BRAF mutation in metastatic melanoma differed from primary melanoma. BRAF mutation was present in 15 of 23 (61%) patients with primary melanoma and in 7 of 12 (58%) patients with metastatic melanoma. These results suggest that BRAF mutation in melanoma is most likely to occur prior to the development of metastatic disease.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.