Perspective

The expanding role of miR-302–367 in pluripotency and reprogramming

Volume 11, Issue 8   April 15, 2012
Pages 1517 - 1523
http://dx.doi.org/10.4161/cc.19846
Authors: Inna Lipchina, Lorenz Studer and Doron Betel

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Abstract:
MicroRNA (miRNA) has been shown to be essential for regulating cell fate and pluripotency; however, our knowledge of miRNA function in stem cells is incomplete due to experimental limitations and difficulties in identifying their physiological targets. Recent studies implicated hESC-expressed miRNAs (miR‑302–367 and miR‑371–373 clusters) in regulating BMP signaling and promoting pluripotency, suggesting that low levels of BMP signaling may promote pluripotency by preventing neural induction. A comprehensive list of miR‑302–367 targets recently identified by genome-wide approaches suggests a number of additional cellular processes and signaling pathways whose regulation by miR‑302–367 may promote pluripotency and reprogramming, such as cell cycle, epigenetic changes, metabolism and vesicular transfer.

Received: February 23, 2012; Accepted: February 28, 2012

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