Extra Views

The role of TRADD in death receptor signaling

Volume 11, Issue 5   March 1, 2012
Pages 871 - 876
http://dx.doi.org/10.4161/cc.11.5.19300
Keywords: MAP kinase, TRADD, apoptosis, death receptor, necrosis
Authors: Yelena L. Pobezinskaya and Zhenggang Liu

View affiliations

Abstract:
TRADD (TNFR1-associated death domain protein) was initially identified as an adaptor molecule that transduces the signal downstream of the TNFR1 (tumor necrosis factor receptor 1). TNFR1 belongs to the so-called death receptor (DR) family of receptors that depending on the context can induce either apoptosis or proliferation, as well as NF-κB and MAP kinase activation. The receptors of this group contain death domain (DD) that is necessary for the induction of apoptosis. This review summarizes the recent advances in the field of DR signaling and in particular the role of TRADD.

Received: November 30, 2011; Accepted: January 9, 2012

Preview:



Advertisements