Sign up for Table of Contents Alerts.
Email this page
Print this page
Extra Views
Developmental Patterning in the Wrong Context: The Paradox of Epithelial Ovarian Cancers
Honami Naora
volume 4 | issue 8
august 2005Pages: 1033-1035
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.
In contrast to many other types of cancer, epithelial ovarian cancers often exhibit differentiation patterns that are more specialized than those of the tissue of origin. Many epithelial ovarian cancers assume morphologic features reminiscent of the müllerian duct-derived epithelia, but are thought to arise from cells of the simple ovarian surface epithelium that is not of müllerian duct origin. This article discusses recent studies that implicate aberrant activation of embryonic pathways in ovarian cancer histogenesis, and highlights the intimate relationship between developmental plasticity and neoplasia.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.