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Perspectives
Cell Division and Hematopoietic Stem Cells: Not Always Exhausting
Carl R. Walkley, Grant A. McArthur and Louise E. Purton
volume 4 | issue 7
july 2005Pages: 893-896
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Pluripotent hematopoietic stem cells (HSCs) sustain blood cell production throughout an individual’s lifespan through complex processes supported by self-renewal, differentiation, senescence or cell death decisions of the HSCs. These decisions are tightly regulated under homeostatic conditions, allowing both the continuous generation of progenitors and mature cells in addition to the maintenance and replenishment of the HSC pool. Several recent studies have provided insights into some of the key molecular mechanisms regulating these different cell fate decisions. One of the emerging themes of these studies is that of the importance of cell cycle regulators in the maintenance of HSCs.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.