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Tumor Profiling Turmoil
Paul Roepman and Frank C.P. Holstege
volume 4 | issue 5
may 2005Pages: 659-660
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Tumor profiling studies aim to determine gene expression signatures that can discriminate between different sub-types of tumors. We have recently discovered a signature that can reliably detect which primary head-neck tumors have metastasized to local lymph nodes. This signature has great potential for clinical application and also offers unique insights into how metastasis occurs. Despite these obvious advances, discussed here alongside several other findings, such tumor profiling studies are currently receiving harsh criticism. We make clear that such evaluations can themselves also be critically evaluated. The separation between the two factions actually shows that it is too early to either dismiss of exalt tumor profiling studies. Final judgment requires waiting for the results of larger prospective studies carried out in parallel with current clinical practice.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.