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Biology using engineering tools: The negative feedback amplifier

Volume 10, Issue 13   July 1, 2011
Pages 2069 - 2076
http://dx.doi.org/10.4161/cc.10.13.16245
Authors: Marc R. Birtwistle and Walter Kolch

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Abstract:
Negative feedback is an ubiquitous feature of biological networks. Recent work from Sturm and colleaguespresents experimental evidence that biological negative feedback can serve the same function as it does for engineered systems: robustness to perturbations within the feedback loop. Such behavior has important implications for how to attack deregulated signaling networks containing negative feedback in diseases such as cancer.

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