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Perspectives
Netrin-Integrin Signaling in Epithelial Morphogenesis, Axon Guidance and Vascular Patterning
Sotiris N. Nikolopoulos and Filippo G. Giancotti
volume 4 | issue 3
march 2005Pages: 429 - 433
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Netrins and their classical receptors - DCC and neogenin - play key roles in neuronal guidance. Recent developments identify new roles for netrins in epithelial and vascular morphogenesis. Netrins accomplish these effects, at least in part, through binding to integrins and/or activating integrin-associated kinases such as FAK and Fyn. Here we discuss these recent findings and propose that integrins and classical netrin receptors cooperate to regulate multiple aspects of development.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.