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Perspectives
An Unusual Gene Dosage Effect of p27kip1 in a Mouse Model of Prostate Cancer
Cory Abate-Shen and Michael M. Shen
volume 4 | issue 3
march 2005Pages: 426 - 428
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Expression of the p27kip1 cell cycle inhibitor is down-regulated in a wide range of carcinomas, yet it is rarely inactivated completely. Our recent studies of a mouse model of prostate carcinogenesis have revealed that cancer progression is enhanced by a two-fold reduction in p27kip1 gene dosage, but is unexpectedly inhibited by further decrease in p27kip1 activity. This paradoxical finding may explain the unusual features of p27kip1 downregulation in human cancer, and also suggests a potential route for therapeutic intervention.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.