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c-Met Signalling: Spatio-Temporal Decisions
S. Kermorgant and P.J. Parker
volume 4 | issue 3
march 2005Pages: 352 - 355
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The spatial control of signalling events is critical in determining the outcome of a cellular response. Recent studies on the signal output from the growth factor/receptor HGF/c-Met, demonstrates that the PKC-regulated location of downstream transducers, specifically the MAPkinase ERK1/2, has a profound positive influence on cell migration, despite apparently reducing the steady state level of ERK1/2 activation. The mechanisms involved and the implications for signalling studies are discussed.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.