Editorials: Cell Cycle Features

Plugging PKA into ERK scaffolds

Volume 10, Issue 5   March 1, 2011
Pages 731 - 732
http://dx.doi.org/10.4161/cc.10.5.14902
Keywords: AKAP, cancer, kinase, network, scaffold, signaling
Authors: F. Donelson Smith, Lorene K. Langeberg and John D. Scott

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Abstract:
Cancers often arise in part through derangements in protein kinase signaling. A striking example of this is the finding that approximately 30% of human tumors have mutations in Ras or B-Raf, leading to aberrant ERK kinase activation. Kinase signaling networks are often organized by scaffolding and anchoring proteins that help shape the dynamics of signal processing. AKAP-Lbc associates with the ERK scaffold protein KSR-1 to organize a growth factor and cAMP responsive signaling network. AKAP-Lbc also directs PKA phosphorylation of KSR-1 on a critical residue to ensure maximal signaling efficiency.

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