Cell migration regulates the kinetics of cytokinesis
Volume 10, Issue 4
Downloads and Tools
February 15, 2011
Pages 648 - 654http://dx.doi.org/10.4161/cc.10.4.14813
Authors: Stephen Wood, Gayathri Sivaramakrishnan, Joanne Engel and Sasha H. Shafikhani View affiliations
Cytokinesis is the final stage of cell division in which the daughter cells separate. Although a growing body of evidence suggests that cell migration-induced traction forces may be required to provide physical assistance for daughter cells to dissociate during abscission, the role of cell migration in cytokinesis has not been directly elucidated. Recently, we have demonstrated that Crk and paxillin, which are pivotal components of the cell migration machinery, localize to the midbody and are essential for the abscission. These findings provided an important link between the cell migration and cytokinesis machineries and prompted us to dissect the role of cell migration in cytokinesis. We show that cell migration controls the kinetics of cleavage furrowing, midbody extension and abscission and coordinates proper subcellular redistribution of Crk and syntaxin-2 to the midbody after ingression.